Cytoplasmic retention signal
WebThis new understanding of the determinants of nuclear retention and cytoplasmic export provides a deeper understanding of how information flow is regulated in eukaryotic cells. Ultimately these processes promote … WebNov 30, 2007 · However, cytoplasmic reaccumulation after ligand removal, although rapid for GFP-Stat3α (t ½ = 15 min), was markedly delayed for GFP-Stat3β (t ½ > 180 min). Prolonged nuclear retention of Stat3β was accompanied by reduced intranuclear mobility and increased immobile fraction.
Cytoplasmic retention signal
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WebMar 1, 2004 · Cytoplasmic retention of signal transducers prevails when cells are poised to receive an extracellular signal, and nuclear … WebNov 12, 2004 · Here we report that the cytoplasmic localization of hHDAC6 is resistant to treatment with leptomycin B (LMB), demonstrate that the SE14 repeat domain is responsible for this resistance, and show that hHDAC6 possesses intrinsic …
WebAug 1, 1994 · Although the cytoplasmic retention signal region is outside the cyclin box, its sequence is well conserved in human cyclin B2, and is both necessary and sufficient … WebJan 21, 2024 · Misfolded and/or unassembled secretory and membrane proteins in the endoplasmic reticulum (ER) may be retro-translocated into the cytoplasm, where they undergo ER-associated degradation, or ERAD. The mechanisms by which misfolded proteins are recognized and degraded through this pathway have been studied …
WebCytokine release syndrome (CRS) is a form of systemic inflammatory response syndrome (SIRS) that can be triggered by a variety of factors such as infections and certain drugs. … ER retention refers to proteins that are retained in the endoplasmic reticulum, or ER, after folding; these are known as ER resident proteins. Protein localization to the ER often depends on certain sequences of amino acids located at the N terminus or C terminus. These sequences are known as signal peptides, molecular signatures, or sorting signals.
WebJun 7, 2007 · We will refer to this sequence as cytoplasmic localization signal (CLS). It could function as a non-canonical signal for nuclear export or as a cytoplasmic retention signal of PTEN. Mutations within the CLS induce nuclear localization and impair growth suppressive activities of PTEN while preserving lipid phosphatase activity.
WebThe ER retention signal of the cytoplasmic domain could not be localized to a single amino acid segment by deletion analysis. These results show that cytochrome P450 2C2 contains redundant, complex ER retention … north lake tahoe express reno nvWebNov 6, 2024 · In this study, we identified that the glycophorin transmembrane domain encoded an ER/Golgi retention signal, which could be counteracted by forward-trafficking signals (i.e., the R18 epitope of GPA/GP.Mur; the cytoplasmic domain of GPA ) … north lake tahoe floristsWebCytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-associated kinase-mediated signal impair expression of p21(Cip1/Waf1) in phorbol 12 … how to say musical in frenchWebThe majority of DDX3 is found in the cytoplasm, but a subset of tumors has distinct nuclear DDX3 localization of yet unknown biological significance. ... DDX3 mutants were created for in vitro evaluation of the mechanism behind nuclear retention of DDX3.Results: DDX3 was present in the nucleus of 35% of colorectal and 48% of breast cancer ... north lake tahoe entertainment calendarWebIntegrins and Signal Transduction. As discussed in Chapters 11 and 12, the integrins are the major receptors responsible for the attachment of cells to the extracellular matrix.At … how to say music in greekWebApr 8, 2014 · When present within 4-residues of the TMD it serves as a Golgi export signal, but when located at the C-terminus of the 68-residue p14 cytoplasmic endodomain it functions as an ER retention signal. The PBM has no effect on protein trafficking when located at an internal position in the cytoplasmic domain. how to say music in japanese hiraganaWebSignal-Based Retention of Golgi Resident Proteins via Carboxy-Terminal Lysine-Based Motifs The glycosylation of proteins and lipids depends on nucleotide-sugar conjugates that are translocated from the cytoplasm into the lumen of the ER or Golgi via multispanning membrane proteins called nucleotide-sugar transporters (NSTs) ( Berninsone and ... how to say music in mandarin